To deliver a biologically-driven gut-brain axis organ-on-chip with a user-friendly design, GUTVIBRATIONS will take a modular approach where modules simulating different regions or functions along the gut-brain axis are separately developed and validated before assembly into the complex gut-brain axis OoC. Each module will comprise of three layers – STACKS, Biosilk, and human organoids.
A 3D printed platform similar to Transwell® inserts. STACKS is easy to fabricate, simple to use, readily scalable, and stackable system in the multiwell plate format.
A biomaterial made from recombinant spider silk protein and can be functionalised with ECM proteins such as laminins to create an organ-specific microenvironmental niche.
Stem cell-derived models that recapitulate organ function and phenotype. Organoids will be supported by other organ-specific primary cells.